Semax
Synthetic ACTH(4-10) Analog
Molecular Details
Overview
Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) fragment 4-10. Developed in Russia in the 1990s, this seven-amino-acid peptide was engineered with enhanced stability through the addition of a Pro-Gly-Pro extension at the C-terminus. The peptide has been studied for its neuroprotective and cognitive-modulatory properties through mechanisms involving neurotrophic factor regulation and neurotransmitter system activation.
Published Research
BDNF/TrkB System Regulation
In vivo (rat) · 2006Semax administration rapidly increased brain-derived neurotrophic factor (BDNF) protein levels in the rat hippocampus by 1.4-fold and elevated trkB tyrosine phosphorylation by 1.6-fold, correlating with improved conditioned avoidance learning.
Ischemic Stroke Gene Expression
Genome-wide profiling (rat) · 2014Genome-wide transcriptional analysis of rat cortex tissue post-ischemia revealed that Semax modulates expression of immune-related and vascular genes, with upregulation of genes supporting new vessel formation during ischemic conditions.
Neurotransmitter System Activation
In vivo (rodent) · 2003Administration of Semax rapidly elevated dopamine and serotonin levels in rodent brain, exhibiting dual monoaminergic activity with effects including antidepressant-like and anxiolytic-like behavioral outcomes.
Amyloid-Beta Aggregation Inhibition
In vitro · 2021Semax inhibited copper-induced amyloid-beta aggregation and amyloid formation in artificial membrane models, demonstrating anti-aggregation properties relevant to neurodegenerative disease research.
Storage & Handling
Store lyophilized powder at –20°C or –80°C. Contains methionine (oxidation-prone) — minimize exposure to light and oxygen. Reconstituted solutions stable 7–14 days refrigerated at 2–8°C. Avoid repeated freeze-thaw cycles.
For research purposes only. Not intended for human consumption. This profile summarizes published preclinical literature and does not constitute medical, clinical, or dosage guidance.