Selank
Synthetic Tuftsin Analog
Molecular Details
Overview
Selank is a synthetic heptapeptide derived from tuftsin, an endogenous immunomodulatory tetrapeptide fragment of immunoglobulin G. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank was engineered by extending the tuftsin core (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro tripeptide to improve metabolic stability and half-life. The peptide exhibits dual properties: immunomodulation and neuromodulation through GABAergic and monoaminergic pathways.
Published Research
GABAergic Gene Expression
In vivo (rat) · 2016Assessment of mRNA levels for 84 genes encoding GABAergic system proteins showed 45 genes with significant expression changes at 1 hour post-administration, with positive correlation between Selank and GABA expression patterns.
Inflammation Gene Dynamics
In vivo (mouse) · 2013Temporal analysis showed Selank modulates complement cascade (C3), inflammasome activation (Casp1), cytokine receptor signaling (Il2rg), and dendritic cell migration (Xcr1), indicating broad immunomodulatory activity.
Antiviral Immune Response
In vitro / In vivo · 2015Studies demonstrated enhanced innate immune activity including increased phagocytic activity of macrophages and neutrophils, and enhanced natural killer cell cytotoxicity against multiple viral pathogens.
Neuroimmune Gene Expression
In vitro (neuroblastoma) · 2017Comparative analysis showed Selank produces a distinct gene expression signature overlapping with but not identical to GABA, suggesting both direct and indirect effects on GABAergic pathways.
Storage & Handling
Store lyophilized powder at –20°C or –80°C in sealed, desiccant-containing vials. Contains arginine and lysine (hygroscopic) — store in tightly sealed containers. Reconstituted solutions: 2–8°C for 7–14 days. Avoid frost-free freezers.
For research purposes only. Not intended for human consumption. This profile summarizes published preclinical literature and does not constitute medical, clinical, or dosage guidance.