Melanotan II
Synthetic Cyclic Melanocortin Receptor Agonist
Molecular Details
Overview
Melanotan II is a synthetic cyclic heptapeptide and non-selective agonist of melanocortin receptors (MC1R, MC3R, MC4R, and MC5R). Developed as a research tool to investigate melanocortin signaling pathways, it is an analog of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). First studied in the 1990s, subsequent research has revealed activity across multiple physiological systems regulated by melanocortin signaling.
Published Research
Peripheral Nerve Regeneration
In vivo (rat) · 2003A rat sciatic nerve crush model demonstrated that melanotan-II enhanced recovery of sensory function following nerve injury and exhibited neuroprotective properties against cisplatin-induced toxic neuropathy.
Appetite & Energy Homeostasis
In vivo (mouse) · 2022Microinjection studies showed that melanotan-II significantly decreased appetitive responding and consumptive intake, contributing to understanding of melanocortin-4 receptor signaling in appetite regulation.
Social Bonding & Behavioral Effects
In vivo (comparative) · 2015Administration in prairie voles enhanced partner preference formation through MC3/MC4 receptor pathways, with species-specific selectivity demonstrating distinct melanocortin-dependent mechanisms in social behavior.
Thermogenic Response
In vivo (mouse) · 2020In PACAP-deficient mice, melanotan-II administration partially rescued impaired thermogenic capacity, indicating cross-pathway interactions between melanocortin and PACAP-dependent systems in thermoregulation.
Storage & Handling
Store lyophilized powder at –20°C to –80°C. Reconstituted solutions: refrigerate at 2–4°C for up to 7 days, or below –20°C for extended storage. Add carrier protein (0.1% HSA or BSA) for long-term reconstituted storage. Protect from moisture and light.
For research purposes only. Not intended for human consumption. This profile summarizes published preclinical literature and does not constitute medical, clinical, or dosage guidance.