Adamax (Non-Amidated)
Non-Amidated Acetylated Semax Analog (Ac-MEHFPGPAG)
Molecular Details
Overview
Adamax is a synthetic nonapeptide derived from Semax (itself an analog of the ACTH(4-7) fragment Met-Glu-His-Phe). It adds an N-terminal acetyl group and a C-terminal Ala-Gly extension to the Semax core, giving the sequence Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly. This listing is the non-amidated (free-acid) form, molecular weight 984.10. As a newer designer analog, Adamax has limited peer-reviewed literature specific to it; most available research pertains to the parent Semax scaffold and the broader family of ACTH- and melanocortin-derived neuropeptides. The molecular data here is provided for identification; the summarized research reflects the parent scaffold rather than clinical evidence for this analog.
Published Research
Parent Scaffold — Semax / ACTH(4-7) Neuromodulation
In vivo (rodent) · 2006Adamax derives from Semax, an analog of the ACTH(4-10)/(4-7) fragment. Research on the parent Semax scaffold has reported rapid increases in brain-derived neurotrophic factor (BDNF) and modulation of neurotrophic signaling in rodent hippocampus. These findings pertain to the parent compound rather than to the Adamax analog specifically.
Parent Scaffold — Gene Expression in Ischemia Models
Genome-wide profiling (rat) · 2014Studies of the Semax scaffold in ischemic models describe modulation of vascular- and immune-related gene expression. As with all entries here, this reflects research on the parent peptide family; independent published data on the Adamax analog itself is limited.
Analog Design Rationale
Structural / Medicinal chemistry · 2020Adamax applies N-terminal acetylation and a C-terminal Ala-Gly extension to the Semax core — modifications of a type generally intended to influence peptide stability. No peer-reviewed clinical literature specific to the Adamax analog was identified; its profile is presented on the basis of its molecular relationship to Semax.
Key Characteristics
- Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ala-Gly (the Ac-MEHFPGP core of Semax plus a C-terminal Ala-Gly extension)
- Molecular weight: 984.10 Da for the non-amidated (free-acid) form listed here; an amidated form (~983 Da) is also described in the market
- Derived from Semax, itself an analog of the ACTH(4-7) fragment Met-Glu-His-Phe
- Despite the brand name, the verified molecular formula (C₄₄H₆₁N₁₁O₁₃S) contains no adamantane group
- A newer designer analog with limited independent peer-reviewed literature; see the Semax profile for parent-scaffold research
Storage & Handling
Store lyophilized powder at –20°C or below. Contains methionine, which is oxidation-prone — minimize exposure to light and air. Reconstituted solutions: refrigerate at 2–8°C and use within 1–2 weeks. Avoid repeated freeze-thaw cycles.
For research purposes only. Not intended for human consumption. This profile summarizes published preclinical literature and does not constitute medical, clinical, or dosage guidance.